Alcohol and the microbiome

An article was recently published in PNAS that investigated the relationship between alcohol dependence and the microbiome.  The authors had previously shown that alcohol-dependent people are at higher risk for a ‘leaky gut’, in which some molecules, such as bacterial metabolites, are passing through the GI tract into the bloodstream.  Leaky guts cause an inflammatory response that leads to further health issues.  In their new study, the authors investigated whether alcohol craving, and depression are associated with the gut microbiome, and suggest the possibility of targeting the microbiome as a therapeutic modality during alcoholism recovery.

The authors studied 60 alcohol dependent subjects who recently stopped drinking and measured their microbiome, leakiness of gut, and mood.  They immediately discovered that the leakiness of the gut was associated with alcohol craving during withdrawal.  The more leaky the gut, the more the subject craved alcohol, whereas patients with less leaky guts had less psychological addictions.

The authors also discovered that leakier guts were associated with microbiome dysbiosis, which included many bacteria associated with inflammatory bowel disease (IBD).  Other studies have shown that similar dysbioses are associated with leaky guts in IBD patients, and in recovering alcoholics the dysbiosis can last long after cessation of drinking.

This study suggests that potential treatments for recovering alcoholics could include targeting the microbiome to bring it back to a more ‘normal’ state.  This normal state will decrease the permeability of the gut (make it less leaky), and thus decrease the psychological addiction to alcohol.

http://www.microbiomeinstitute.org/blog/2014/10/8/alcoholism-and-the-microbiome

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Coca-Cola to move into alcohol in the Japanese market.

Jorge Garduño, president of the company’s Japan business unit, said that there are plans to ”experiment” with Chu-Hi, a canned alcoholic drink popular in Japan.

“This is a canned drink that includes alcohol; traditionally, it is made with a distilled beverage called shōchū and sparkling water, plus some flavouring,” Garduño explained in an interview on the company’s website.

“We haven’t experimented in the low-alcohol category before, but it’s an example of how we continue to explore opportunities outside our core areas.”

The company, which launched in 1886, is best known for its flagship soft drink brand, Coca-Cola.

Garduño said that historically the company has “always focused entirely” on the non-alcoholic category.

He continued: “Globally, it’s not uncommon for non-alcoholic beverages to be sold in the same system as alcoholic beverages. It makes sense to give this a try in our market. But I don’t think people around the world should expect to see this kind of thing from Coca-Cola.

“While many markets are becoming more like Japan, I think the culture here is still very unique and special, so many products that are born here will stay here.”

This is not the first time the company has shown an interest in alcohol. The soft drinks giant was involved in the wine industry from 1977 to 1983 through its Wine Spectrum unit, which it sold to Seagram’s in November 1983.

According to a recent report, global spirits consumption is predicted to hit 3.16 billion cases by 2021, with ‘national spirits’ such as baijiu, soju and Indian whisky retaining significant market share.

https://www.thespiritsbusiness.com/2018/03/coca-cola-to-launch-first-alcoholic-product/

 

Coca-Cola to move into alcohol in the Japanese market.

Jorge Garduño, president of the company’s Japan business unit, said that there are plans to ”experiment” with Chu-Hi, a canned alcoholic drink popular in Japan.

“This is a canned drink that includes alcohol; traditionally, it is made with a distilled beverage called shōchū and sparkling water, plus some flavouring,” Garduño explained in an interview on the company’s website.

“We haven’t experimented in the low-alcohol category before, but it’s an example of how we continue to explore opportunities outside our core areas.”

The company, which launched in 1886, is best known for its flagship soft drink brand, Coca-Cola.

Garduño said that historically the company has “always focused entirely” on the non-alcoholic category.

He continued: “Globally, it’s not uncommon for non-alcoholic beverages to be sold in the same system as alcoholic beverages. It makes sense to give this a try in our market. But I don’t think people around the world should expect to see this kind of thing from Coca-Cola.

“While many markets are becoming more like Japan, I think the culture here is still very unique and special, so many products that are born here will stay here.”

This is not the first time the company has shown an interest in alcohol. The soft drinks giant was involved in the wine industry from 1977 to 1983 through its Wine Spectrum unit, which it sold to Seagram’s in November 1983.

According to a recent report, global spirits consumption is predicted to hit 3.16 billion cases by 2021, with ‘national spirits’ such as baijiu, soju and Indian whisky retaining significant market share.

https://www.thespiritsbusiness.com/2018/03/coca-cola-to-launch-first-alcoholic-product/